The capsule contains pineapple powder, shatavari, L-citrulline DL-malate, black cumin seed, beet root and hibiscus extracts, and the company describes what studies show, and where evidence is limited, for each
TALLMADGE, Ohio, Oct. 6, 2026 — Flush Factor Plus today announced the U.S. availability of its daily dietary supplement for adults. The capsule contains six plant-derived and amino acid ingredients and, according to the company, no stimulants. The recommended serving is one capsule per day with plenty of water. The company states that the product is not intended to diagnose, treat, cure or prevent any disease, including conditions that cause swelling in the legs, ankles or feet.
The formula contains pineapple powder, Asparagus racemosus (shatavari) extract, L-citrulline DL-malate, black cumin seed extract, beet root extract and Hibiscus sabdariffa flower extract. The ingredients appear as a proprietary blend. Flush Factor Plus states that the product is manufactured in the United States in an FDA-registered facility that follows Good Manufacturing Practice (GMP) guidelines.
With the announcement, Flush Factor Plus is publishing a summary of the published research on each ingredient. The summary includes findings that do not support some common assumptions about these ingredients.
“Most of the published research on these six ingredients is about blood pressure. Very little of it is about legs,” said James Smith, Media Relations at Flush Factor Plus. “We would rather state that in a press release than leave people to find out after they buy. The summary lists what was studied, in whom, at what dose, and what the results were.”
Formula Overview
The six ingredients fall into three groups based on how they have been studied:
- Four ingredients studied mainly for blood pressure and blood vessel function: L-citrulline DL-malate, beet root, hibiscus and black cumin seed.
- One ingredient with a long history of traditional use and limited human research: shatavari.
- One fruit powder that contains the enzyme mixture bromelain: pineapple.
The company does not state that the product changes hormone levels, fluid balance or the cause of any swelling. Several of the ingredients below can lower blood pressure or affect urine output, so the research summary includes interaction information alongside each finding.
L-Citrulline: Studied for Blood Pressure at Gram-Level Doses
L-citrulline is an amino acid found in watermelon and used in supplements. The body converts it to L-arginine, which is used to make nitric oxide, a molecule involved in widening blood vessels.
A systematic review and meta-analysis in Avicenna Journal of Phytomedicine pooled 8 randomized trials of oral L-citrulline in adults and reported that supplementation may reduce systolic blood pressure [1]. The doses ranged from 3 to 9 grams per day, and a reduction in diastolic pressure appeared only in trials using 6 grams or more per day.
Those trials measured blood pressure, not leg swelling or fluid retention. The participants ranged in age from 22 to 71, and the trials differed in design and length. Results at the doses used in these trials cannot be assumed at other amounts.
Beet Root: Evidence Comes Mainly From Juice Trials
Beet root contains inorganic nitrate, which the body can convert to nitric oxide.
A systematic review and meta-analysis in the Journal of Nutrition included 16 randomized trials of nitrate and beetroot juice in 254 participants and found an average systolic blood pressure reduction of 4.4 mm Hg [2]. The change in diastolic pressure was smaller and not statistically significant. Individual trials were small, with 7 to 30 participants each, and most tested juice or nitrate salts, not dried extract in capsules. The authors recommended testing the findings in long-term trials and in people at higher cardiovascular risk.
Hibiscus: Blood Pressure Findings With a Dose Threshold
Hibiscus sabdariffa flowers are used in teas and herbal products.
A meta-analysis of 17 randomized trials in Nutrition Reviews reported that hibiscus lowered systolic blood pressure by an average of 7.1 mm Hg compared with placebo, with larger reductions in people whose blood pressure was elevated at the start [3]. Results varied widely between trials. In studies that examined dose, amounts of 1 gram per day or less did not produce significant results.
The effect of hibiscus on leg swelling has not been established in these trials. Because hibiscus can lower blood pressure, people taking blood pressure medication should consult a healthcare professional before use.
Black Cumin Seed: Inconsistent Results
Black cumin (Nigella sativa) seed has been used in traditional medicine across several regions.
A 2024 meta-analysis in the Journal of Nephropathology reported that black cumin seed powder and oil lowered systolic and diastolic blood pressure [4]. A separate 2024 systematic review in the West African Journal of Medicine found a significant blood pressure improvement in only 1 of 5 trials and described the blood pressure results as inconsistent across studies [5]. Most trials used powder or oil, and the Flush Factor Plus formula contains a seed extract.
Shatavari and Pineapple: Limited Evidence for Leg-Related Use
Shatavari (Asparagus racemosus) is a root used in Ayurvedic medicine. Reference monographs report no good scientific evidence for its common uses [6]. Animal studies show diuretic effects at high doses. Based on that finding, shatavari may add to the effects of diuretic medicines, lower potassium levels and reduce the body’s excretion of lithium, which could raise lithium levels [6]. Information on its safety during pregnancy and breastfeeding is insufficient.
Pineapple powder contains bromelain, an enzyme mixture studied mainly for swelling and pain after surgery or injury. Evidence for those uses is mixed, and it is rated insufficient for chronic venous insufficiency, a condition of the leg veins [7]. Bromelain might slow blood clotting and may increase bleeding risk when combined with blood thinners [7]. The product contains pineapple powder, not a standardized bromelain extract.
What Ingredient Research Does and Does Not Show
The research summary separates three questions: what each ingredient is, what researchers have found about it, and what has been demonstrated about the finished capsule.
The strongest findings above concern blood pressure in adults, mostly at doses and in forms that may differ from those in the capsule. For shatavari and pineapple powder, human evidence for any leg-related use is limited or rated insufficient. Several studies also used foods, juices or powders, which can differ from extracts in strength and composition. The finished formula has not been evaluated in published clinical trials, and the company does not present it as clinically evaluated or attribute ingredient-level findings to the complete capsule.
“If an ingredient has no human data on leg swelling, the summary says so. If a study found no effect, the summary says that too,” said James Smith. “A reader can then compare the evidence with their own reason for taking a supplement and decide whether the two match.”
Safety and Suitability
Flush Factor Plus is intended for healthy adults. Because several ingredients may lower blood pressure, affect urine output or slow blood clotting, people in the following situations should consult a qualified healthcare professional before use:
- take blood pressure medication or have low blood pressure
- take diuretics (“water pills”) or lithium
- take blood thinners or antiplatelet medicines, or are scheduled for surgery
- have heart, kidney or liver disease
- are pregnant, nursing or planning a pregnancy
- have an allergy to pineapple or to plants in the asparagus family
Swelling in the legs, ankles or feet can result from heart failure, kidney disease, liver damage, weakened leg veins or medicines, including some blood pressure drugs [8]. Sudden swelling in one leg, especially with pain, can indicate a blood clot in a deep vein and requires prompt medical care [8]. A supplement is not a substitute for evaluation of persistent or unexplained swelling.
The product is not intended for children. Consumers should follow the label directions and should not exceed the recommended serving of one capsule per day. The Supplement Facts panel on the product label is the definitive source for ingredient amounts, directions and warnings.
Product Format and Availability
Flush Factor Plus is available to U.S. consumers through its website, where purchase options are listed. The product is a capsule, and the recommended serving is one capsule per day with plenty of water. The product is manufactured in the United States in an FDA-registered facility that follows GMP guidelines. It is backed by a 60-day money-back guarantee, and orders are processed by ClickBank.
FDA facility registration and Good Manufacturing Practice compliance relate to manufacturing standards, identity, purity and quality controls. They do not indicate FDA approval of the product or its claims.
About Flush Factor Plus
Flush Factor Plus is a Tallmadge, Ohio-based dietary supplement brand. Its capsule contains pineapple powder, shatavari, L-citrulline DL-malate, black cumin seed, beet root and hibiscus extracts and is manufactured in an FDA-registered facility that follows GMP guidelines. With this announcement, the company is publishing a summary of the research on each ingredient, including studies that did not find a benefit.
References
- Barkhidarian B, Khorshidi M, Shab-Bidar S, Hashemi B. Effects of L-citrulline supplementation on blood pressure: a systematic review and meta-analysis. Avicenna Journal of Phytomedicine. 2019;9(1):10–20.
- Siervo M, Lara J, Ogbonmwan I, Mathers JC. Inorganic nitrate and beetroot juice supplementation reduces blood pressure in adults: a systematic review and meta-analysis. Journal of Nutrition. 2013;143(6):818–826.
- Ellis LR, Zulfiqar S, Holmes M, et al. A systematic review and meta-analysis of the effects of Hibiscus sabdariffa on blood pressure and cardiometabolic markers. Nutrition Reviews. 2022;80(6).
- Fakhri M, Yousofpour M, Moosazadeh M, et al. Determination of the effect of Nigella sativa on blood pressure: a systematic review and meta-analysis of randomized clinical trials. Journal of Nephropathology. 2024;13(1):e21474.
- Systematic review of randomized controlled trials in uses of Nigella sativa (black seed) in metabolic syndrome. West African Journal of Medicine. 2024;41(4):372–380.
- WebMD. Asparagus racemosus (Natural Medicines monograph).
- RxList. Bromelain; Epocrates. Bromelain reported uses and effectiveness ratings.
- Mayo Clinic. Edema; Leg swelling.
Media Contact
James Smith, Media Relations
Flush Factor Plus
285 Northeast Ave, Tallmadge, OH 44278, United States
Email: contact@flushfactorplus-product.com
Phone: 1-800-390-6035
Website: flushfactorplus.com
These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease. Research referenced in this release concerns individual ingredients and does not constitute clinical evaluation of the complete Flush Factor Plus formula or endorsement by the cited researchers, journals, institutions or government agencies.
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